A Clinically Relevant Model for Chronic Kidney Disease in Cats

Overview and Advantages

Chronic kidney disease (CKD) is one of the most common chronic, non-communicable diseases in senior cats, affecting over 30% of aging feline populations. Characterized by a slow, irreversible progression, CKD significantly reduces quality of life and presents a major challenge in veterinary medicine.

YiJi Biology has developed a standardized feline CKD model that accurately replicates key pathological features of chronic renal dysfunction. Built on advanced animal health monitoring and biochemical control systems, this model is designed for high stability and reproducibility, making it ideal for drug development across multiple stages.

Strong Clinical Relevance

Aligned with the IRIS (International Renal Interest Society) CKD staging system, with biochemical and behavioral endpoints that closely mirror disease progression.

Comprehensive Multi-Parameter Assessment

Includes blood, urine, physiological, and behavioral indicators for a holistic evaluation.

Controlled Chronic Progression

Enables mid- to long-term drug intervention studies and continuous efficacy monitoring.

Standardized Data Output

Generates consistent, publication-ready data suitable for regulatory submissions and international collaborations.

Key Pathological & Clinical Features

CategoryIndicators & Observations
Renal Function MarkersSustained elevation of SDMA, CREA, and BUN; SDMA >18 indicating reduced glomerular filtration rate (GFR).
Kidney UltrasoundRenal size reduction by 20–40% on longitudinal ultrasound imaging.
UrinalysisIncreased urine protein-to-creatinine ratio (UP/C ≥ 0.2).
Blood PressureElevated systolic blood pressure (measured via Doppler).
Behavioral ChangesReduced appetite, weight loss, and decreased activity, reflecting chronic discomfort.
Disease ProgressionDistinct acute kidney injury (AKI) and CKD phases, supporting phased efficacy evaluation.

CRO Support & Custom Services

We offer full-service CRO support tailored to this model, including:

Customized study design and in vivo experimentation.

Multi-timepoint biomarker collection and statistical analysis.

Behavioral monitoring and scoring.

GCP-compliant study documentation and reporting.

Regulatory dossier preparation and submission support.

Interested in learning more?

Contact Us for detailed model information and service collaboration opportunities.