A Clinically Relevant Model for Chronic Pain in Cats

Our validated feline chronic pain model enables the preclinical evaluation of novel analgesic therapies with high translational value, addressing a critical unmet need in companion animal drug development.

Overview and Advantages

Chronic pain is a highly prevalent yet often underdiagnosed condition in cats, particularly in aging populations with osteoarthritis and neuropathic disorders. Due to the subtle behavioral signs in cats, traditional assessment methods often fail to capture the true efficacy of analgesic treatments.

YiJi Biology has developed a standardized feline chronic pain model based on advanced behavioral analytics and long-term animal management expertise. This model has been widely adopted by veterinary pharmaceutical companies and academic institutions for the preclinical assessment of novel pain therapeutics.

Clear Behavioral Endpoints

Scientifically validated pain assessments using video tracking and scoring systems.

Stable Pain Duration

Consistent pain behaviors maintained for 14 to 21 days, enabling multi-stage intervention studies.

FDA-Inspired Design

Aligned with the evaluation frameworks used for FDA-approved drugs, ensuring high translational relevance.

Multi-Dimensional Monitoring

Combines subjective pain scoring and objective gait analysis, with traceable datasets.

Key Behavioral Indicators

Category	Observations & Metrics
Gait Behavior	Stiff walking, reduced jumping frequency, slower movements
Activity Scoring	Decreased spontaneous activity, increased sensitivity to stimuli
Video Tracking	Altered movement patterns, reduced activity frequency
Treatment Response	Dose-dependent behavioral improvement following drug intervention
Observation Window	Pain behaviors sustained for 14-21 days, suitable for efficacy tracking

Gait Behavior in Feline Chronic Pain Model

Gait Improvement Following Analgesic Treatment

CRO Support & Custom Services

We offer full-service CRO support tailored to this model, including:

Behavioral model establishment and multi-group study design

Video capture and professional scoring (BORIS-based)

Pharmacodynamic evaluation and statistical analysis

Study reporting and regulatory documentation

Joint development or customized model services available

Interested in this model or need a customized study?

Contact Us to discuss your research goals.