A Translational Model for Hypertrophic Cardiomyopathy in Cats

Hypertrophic cardiomyopathy (HCM) is the most common primary cardiac disorder in cats, particularly prevalent in genetically predisposed breeds such as Maine Coons and Ragdolls. Severe cases can lead to heart failure, thromboembolism, or sudden cardiac death.

YiJi Biology has developed a standardized feline HCM model that successfully replicates key pathological features of the disease, including left ventricular wall thickening, atrial enlargement, and impaired cardiac function. Our model, established through selective breeding and functional induction protocols, offers high stability, clear disease staging, and strong reproducibility—making it a valuable tool for both veterinary cardiology drug development and translational human cardiovascular research.