Cardiovascular Model
- Feline Hypertrophic Cardiomyopathy (HCM) Model: MYBPC3 gene mutation model, homologous to human HCM. Recapitulates myocardial hypertrophy, left atrial enlargement, and LVOT obstruction. Suitable for both veterinary cardiology and translational human cardiovascular research.
Renal Disease Models
- Feline Chronic Kidney Disease (CKD) Model: Progressive CKD model based on IRIS staging criteria. Supports nephroprotective drug screening, anti-fibrotic studies, and long-term pharmacological evaluations.
- Feline Polycystic Kidney Disease (PKD) Model: PKD1 gene mutation model, homologous to human polycystic kidney disease. Ideal for studies on cystic renal disease mechanisms and therapy development.
Pain Model
- Feline Chronic Pain Model: Induced by subcutaneous plantar kaolin injection, mimicking chronic pain syndromes such as osteoarthritis and neuropathy. Validated for preclinical evaluation of analgesic therapies, including anti-NGF agents and NSAIDs.
Ophthalmic Models
- Feline Glaucoma Models
- Congenital glaucoma model.
- Induced glaucoma model via anterior chamber methylcellulose injection.
Infectious Disease Models
- Feline Immunodeficiency Virus (FIV) Infection Model: FIV challenge model for studying immunodeficiency therapies and vaccines.
- Feline Infectious Peritonitis (FIP) Infection Model: FIP challenge model for antiviral drug testing and immunotherapy research.
- Other Infectious Disease Models: Custom pathogen challenge models for feline infectious diseases.
Metabolic and Neurological Models
- Feline Diabetes Mellitus Model: Stable diabetic cat model for evaluating antidiabetic agents and metabolic interventions.
- Spontaneous Feline Alzheimer’s Disease (AD)-like Model: Naturally occurring cognitive decline model for neurodegenerative research.